SrasV1, Main, Exploration, bibRecord, 003676

Inhibition of SARS coronavirus helicase by bismuth complexes.

Identifieur interne : 003676 ( Main/Exploration ); précédent : 003675; suivant : 003677

Inhibition of SARS coronavirus helicase by bismuth complexes.

Auteurs : Nan Yang [République populaire de Chine] ; Julian A. Tanner ; Zai Wang ; Jian-Dong Huang ; Bo-Jian Zheng ; Nianyong Zhu ; Hongzhe Sun

Source :

Chemical communications (Cambridge, England) [ 1359-7345 ] ; 2007.

RBID : pubmed:17957304

Descripteurs français

KwdFr :
- Adenosine triphosphatases (antagonistes et inhibiteurs), Antienzymes (pharmacologie), Antienzymes (synthèse chimique), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Bismuth (), Chromatographie en phase liquide à haute performance, Composés organométalliques (pharmacologie), Composés organométalliques (synthèse chimique), Cristallographie aux rayons X, Diméthylsulfoxyde, Helicase (antagonistes et inhibiteurs), Modèles moléculaires, Porphyrines (pharmacologie), Porphyrines (synthèse chimique), Virus du SRAS (enzymologie), Zinc ().
MESH :
- antagonistes et inhibiteurs : Adenosine triphosphatases, Helicase.
- enzymologie : Virus du SRAS.
- pharmacologie : Antienzymes, Antiviraux, Composés organométalliques, Porphyrines.
- synthèse chimique : Antienzymes, Antiviraux, Composés organométalliques, Porphyrines.
- Bismuth, Chromatographie en phase liquide à haute performance, Cristallographie aux rayons X, Diméthylsulfoxyde, Modèles moléculaires, Zinc.

English descriptors

KwdEn :
- Adenosine Triphosphatases (antagonists & inhibitors), Antiviral Agents (chemical synthesis), Antiviral Agents (pharmacology), Bismuth (chemistry), Chromatography, High Pressure Liquid, Crystallography, X-Ray, DNA Helicases (antagonists & inhibitors), Dimethyl Sulfoxide, Enzyme Inhibitors (chemical synthesis), Enzyme Inhibitors (pharmacology), Models, Molecular, Organometallic Compounds (chemical synthesis), Organometallic Compounds (pharmacology), Porphyrins (chemical synthesis), Porphyrins (pharmacology), SARS Virus (enzymology), Zinc (chemistry).
MESH :
- chemical , antagonists & inhibitors : Adenosine Triphosphatases, DNA Helicases.
- chemical , chemical synthesis : Antiviral Agents, Enzyme Inhibitors, Organometallic Compounds, Porphyrins.
- chemical , chemistry : Bismuth, Zinc.
- chemical , pharmacology : Antiviral Agents, Enzyme Inhibitors, Organometallic Compounds, Porphyrins.
- enzymology : SARS Virus.
- Chromatography, High Pressure Liquid, Crystallography, X-Ray, Dimethyl Sulfoxide, Models, Molecular.

Abstract

A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.

DOI: 10.1039/b709515e
PubMed: 17957304

Affiliations:

République populaire de Chine

Le document en format XML

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<author><name sortKey="Yang, Nan" sort="Yang, Nan" uniqKey="Yang N" first="Nan" last="Yang">Nan Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.</nlm:affiliation>
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<wicri:regionArea>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong</wicri:regionArea>
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<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
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<term>Bismuth (chemistry)</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Crystallography, X-Ray</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>Dimethyl Sulfoxide</term>
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<term>Models, Molecular</term>
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<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
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<term>Porphyrines (synthèse chimique)</term>
<term>Virus du SRAS (enzymologie)</term>
<term>Zinc ()</term>
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<term>DNA Helicases</term>
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<term>Enzyme Inhibitors</term>
<term>Organometallic Compounds</term>
<term>Porphyrins</term>
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<term>Porphyrines</term>
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<front><div type="abstract" xml:lang="en">A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.</div>
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Serveur d'exploration SRAS

Inhibition of SARS coronavirus helicase by bismuth complexes.

Inhibition of SARS coronavirus helicase by bismuth complexes.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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